Effect of orlistat in obese patients with binge eating disorder

About this resource

OBJECTIVE: Binge eating disorder represents a significant public health problem, with up to 50 % of weight loss program participants displaying this disorder. In previous studies with orlistat, patients with binge eating disorder were excluded. The goal of this study was to assess the efficacy of orlistat in obese patients with binge eating disorder. RESEARCH METHODS AND PROCEDURES: Eighty-nine patients with clinically diagnosed binge eating disorder and a BMI textgreater or = 30 kg/m2 were randomized in double-blind fashion to 24 weeks of treatment with 120 mg of orlistat or placebo three times daily, in combination with a mildly reduced-calorie diet. RESULTS: After 24 weeks, the mean weight loss from baseline for orlistat-treated patients was significantly greater than for patients receiving placebo (-7.4 % vs. -2.3 % ; p = 0.0001) (intent-to-treat analysis). The overall Eating Disorder Inventory 2 score at week 24 was significantly lower in patients treated with orlistat than in those in the placebo group (p = 0.011). DISCUSSION: Orlistat may be considered as part of the management for patients with obesity and binge eating disorder.

AuthorGolay, Alain; Laurent-Jaccard, Anne; Habicht, Frank; Gachoud, Jean-Pierre; Chabloz, Mireille; Kammer, Anne & Schutz, Yves
JournalObesity Research

See also

Lisdexamfetamine dimesylate effects on binge eating behaviour and obsessive-compulsive and impulsive features in adults with binge eating disorder

In a published 11-week, placebo-controlled trial, 50 and 70 mg/d lisdexamfetamine dimesylate (LDX), but not 30 mg/d LDX, significantly reduced binge eating days (primary endpoint) in adults with binge eating disorder (BED).

Read more

Depression, stress and body fat are associated with binge eating in a community sample of African American and Hispanic women

Objective: The purpose of this study was to examine the relationships among depressive symptoms, stress and severity of binge eating symptoms in a community sample of African American and Hispanic or Latina women.

Read more

Assessment of executive functioning in binge-eating disorder independent of weight status

Objective: Executive functioning (EF) problems may serve as vulnerability or maintenance factors for Binge-Eating Disorder (BED).

Read more

Treatment of binge eating disorder with sertraline: A randomized controlled trial

Binge Eating Disorder (BED) is one of the most frequent eating disorders in industrialized societies.

Read more

Help us improve!

Give us feedback!

We will continue throughout 2020 to update and improve the NEDC website and welcome any feedback you may have on the site.

Provide feedback