Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: A randomized double-blind placebo-controlled comparison

About this resource

Cognitive behavioral therapy (CBT) and certain medications have been shown to be effective for binge eating disorder (BED), but no controlled studies have compared psychological and pharmacological therapies. We conducted a randomized, placebo-controlled study to test the efficacy of CBT and fluoxetine alone and in combination for BED. 108 patients were randomized to one of four 16-week individual treatments: fluoxetine (60 mg/day), placebo, CBT plus fluoxetine (60 mg/day) or CBT plus placebo. Medications were provided in double-blind fashion. Of the 108 patients, 86 (80 % ) completed treatments. Remission rates (zero binges for 28 days) for completers were: 29 % (fluoxetine), 30 % (placebo), 55 % (CBT+fluoxetine), and 73 % (CBT+placebo). Intent-to-treat (ITT) remission rates were: 22 % (fluoxetine), 26 % (placebo), 50 % (CBT+fluoxetine), and 61 % (CBT+placebo). Completer and ITT analyses on remission and dimensional measures of binge eating, cognitive features, and psychological distress produced consistent findings. Fluoxetine was not superior to placebo, CBT+fluoxetine and CBT+placebo did not differ, and both CBT conditions were superior to fluoxetine and to placebo. Weight loss was modest, did not differ across treatments, but was associated with binge eating remission. CBT, but not fluoxetine, demonstrated efficacy for the behavioral and psychological features of BED, but not obesity.

AuthorGrilo, Carlos M.; Masheb, Robin M. & Wilson, G. Terence
JournalBiological Psychiatry

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