Structural magnetic resonance imaging in eating disorders: A systematic review of voxel-based morphometry studies

About this resource

This systematic review summarises and critically appraises the literature on structural magnetic resonance imaging in people with a current or past eating disorder. Studies using voxel-based morphometry image analysis were included. Ten studies reported on a total of 236 people with a current or past eating disorder and 257 healthy controls. Sample heterogeneity prohibited a meta-analytic approach. The findings do not unequivocally indicate grey or white matter volume abnormalities in people with an eating disorder. Nevertheless, these preliminary data suggest that, compared with healthy controls, people with anorexia nervosa have decreased grey matter in a range of brain regions and that those with bulimia nervosa have increased grey matter volumes in frontal and ventral striatal areas. Research in the recovery phase and longitudinal studies suggest that potential brain tissue abnormalities may recover with clinical improvement. Overall, as the available data are inconclusive, further efforts in this field are warranted.

AuthorVan Den Eynde, Frederique; Suda, Masashi; Broadbent, Hannah; Guillaume, Sebastien; Van Den Eynde, Magali; Steiger, Howard; Israel, Mimi; Berlim, Marcelo; Giampietro, Vincent; Simmons, Andrew; Treasure, Janet; Campbell, Iain & Schmidt, Ulrike
JournalEuropean Eating Disorders Review
Volume20(2):94-105
Year2012

See also

The MOSAIC study - comparison of the Maudsley Model of Treatment for Adults with Anorexia Nervosa (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with anorexia nervosa or eating disorder not otherwise specified, anorexia nerv

BACKGROUND: Anorexia nervosa (AN) is a biologically based serious mental disorder with high levels of mortality and disability, physical and psychological morbidity and impaired quality of life.

Read more

Pediatric feeding and eating disorders: Current state of diagnosis and treatment

The Diagnostic and Statistical Manual of Mental Disorders now recognizes six primary feeding and eating disorders including pica, rumination disorder, avoidant/restrictive food intake disorder, anorexia nervosa, bulimia nervosa and binge-eating disorder.

Read more

A systematic review of reviews of neurocognitive functioning in eating disorders: The state-of-the-literature and future directions.

OBJECTIVE: In recent years there has been increasing clinical and empirical interest in neurocognitive functioning in eating disorders (EDs), which has resulted in numerous quantitative and qualitative reviews.

Read more

Body composition in men with anorexia nervosa: Longitudinal study

Objective: To compare body composition patterns before and after complete weight restoration in men with anorexia nervosa.

Read more

Help us improve!

Give us feedback!

We will continue throughout 2020 to update and improve the NEDC website and welcome any feedback you may have on the site.

Provide feedback